Technological advancements in information systems over the past few decades have enabled firms to work with the major suppliers and customers in their supply chain in order to improve the performance of the entire channel. Tremendous benefits for all parties can be realized by sharing information and coordinating operations to reduce inventory requirements, improve quality, and increase customer satisfaction; but the companies must collaborate effectively to bring these gains to fruition. We consider two alternative methods of managing these interfirm supply (...) chain relationships in this article. The first, which we have named “dictatorial collaboration,” occurs when a dominant supply chain entity assumes control of the channel and forces the other firms to follow its edicts. We compare and contrast this method with “sustainable collaboration,” in which the parties share resources and engage in joint problem solving to improve the performance of the system as a whole. We use a virtue ethics lens to describe these methods of relationship management to suggest that sustainable collaboration is preferable to dictatorial collaboration both operationally and ethically in the long run. (shrink)

To assess ethics pedagogy in science and engineering, we developed a new tool called the Engineering and Science Issues Test (ESIT). ESIT measures moral judgment in a manner similar to the Defining Issues Test, second edition, but is built around technical dilemmas in science and engineering. We used a quasi-experimental approach with pre- and post-tests, and we compared the results to those of a control group with no overt ethics instruction. Our findings are that several (but not all) stand-alone classes (...) showed a significant improvement compared to the control group when the metric includes multiple stages of moral development. We also found that the written test had a higher response rate and sensitivity to pedagogy than the electronic version. We do not find significant differences on pre-test scores with respect to age, education level, gender or political leanings, but we do on whether subjects were native English speakers. We did not find significant differences on pre-test scores based on whether subjects had previous ethics instruction; this could suggest a lack of a long-term effect from the instruction. (shrink)

The original comic version of T'Challa is a traditional monarch, whose actions demonstrate his concern for maintaining power and securing his nation. In fact, with his strategic use of violence, his demonstrations of empathy and humanity, and his embrace of religious symbolism, T'Challa was classically “Machiavellian” in the comics. "Panther's Rage" chronicles T'Challa's return to Wakanda after an extended stay in the United States as a costumed superhero, most notably with the Avengers. Machiavelli would approve of T'Challa's embrace of violence. (...) Machiavelli was keenly aware of how a ruler should be perceived by his subjects, suggesting that a successful ruler will appear to possess five key qualities that meet with the approval of his subjects: mercy, faith, honesty, humanity, and religion. T'Challa is never as cruel as some of Machiavelli's models, but he does preserve his divinely ordained kingdom by employing fear and religion to stay in power. (shrink)

This paper concerns virtue-based ethical principles that bear upon agricultural uses of technologies, such as GM crops and CRISPR crops. It does three things. First, it argues for a new type of virtue ethics approach to such cases. Typical virtue ethics principles are vague and unspecific. These are sometimes useful, but we show how to supplement them with more specific virtue ethics principles that are useful to people working in specific applied domains, where morally relevant domain-specific conditions recur. We do (...) this while still fulfilling the need for principles and associated practical reasoning to flexibly respect variation between cases. Second, with our more detailed approach we criticize and improve upon a commonly discussed principle about ecosystemic external goods that are crucial for human flourishing. We show this principle is far more conservative than appreciated, as it would prohibit many technology uses that are uncontroversially acceptable. We then replace this principle with two more specific ones. One identifies specific conditions in which ecosystem considerations are against a technology use, the other identifies favorable conditions. Third, we uncover a humility-based principle that operates within an influential “hubris argument” against uses of several biotechnologies in agriculture. These arguments lack a substantive theory of the nature of humility. We clarify such a theory, and then use it to replace the uncovered humility-based principle with our own more specific one that shifts focus from past moral failings, to current epistemic limits when deciding whether to support new technologies. (shrink)

The idea that science is or should be value-free, and that values are or should be formed independently of science, has been under fire by philosophers of science for decades. Science and Moral Imagination directly challenges the idea that science and values cannot and should not influence each other. Matthew J. Brown argues that science and values mutually influence and implicate one another, that the influence of values on science is pervasive and must be responsibly managed, and that science (...) can and should have an influence on our values. This interplay, he explains, must be guided by accounts of scientific inquiry and value judgment that are sensitive to the complexities of their interactions. Brown presents scientific inquiry and value judgment as types of problem-solving practices and provides a new framework for thinking about how we might ethically evaluate episodes and decisions in science, while offering guidance for scientific practitioners and institutions about how they can incorporate value judgments into their work. His framework, dubbed "the ideal of moral imagination," emphasizes the role of imagination in value judgment and the positive role that value judgment plays in science. (shrink)

Spinoza was one of the most influential figures of the Enlightenment, but his often obscure metaphysics makes it difficult to understand the ultimate message of his philosophy. Although he regarded freedom as the fundamental goal of his ethics and politics, his theory of freedom has not received sustained, comprehensive treatment. Spinoza holds that we attain freedom by governing ourselves according to practical principles, which express many of our deepest moral commitments. Matthew J. Kisner focuses on this theory and presents (...) an alternative picture of the ethical project driving Spinoza's philosophical system. His study of the neglected practical philosophy provides an accessible and concrete picture of what it means to live as Spinoza's ethics envisioned. (shrink)

n 1909, the 50th anniversary of both the publication of Origin of the Species and his own birth, John Dewey published "The Influence of Darwin on Philosophy." This optimistic essay saw Darwin's advance not only as one of empirical or theoretical biology, but a logical and conceptual revolution that would shake every corner of philosophy. Dewey tells us less about the influence that Darwin exerted over philosophy over the past 50 years and instead prophesied the influence it would take in (...) the future. I will discuss this landmark paper and the key lessons Dewey draws from Darwinism for philosophy, and give a preliminary assessment of how well we've done so far. (shrink)

The original development of the formalism of quantum mechanics involved the study of isolated quantum systems in pure states. Such systems fail to capture important aspects of the warm, wet, and noisy physical world which can better be modelled by quantum statistical mechanics and local quantum field theory using mixed states of continuous systems. In this context, we need to be able to compute quantum probabilities given only partial information. Specifically, suppose that B is a set of operators. This set (...) need not be a von Neumann algebra. Simple axioms are proposed which allow us to identify a function which can be interpreted as the probability, per unit trial of the information specified by B, of observing the (mixed) state of the world restricted to B to be σ when we are given ρ – the restriction to B of a prior state. This probability generalizes the idea of a mixed state (ρ) as being a sum of terms (σ) weighted by probabilities. The unique function satisfying the axioms can be defined in terms of the relative entropy. The analogous inference problem in classical probability would be a situation where we have some information about the prior distribution, but not enough to determine it uniquely. In such a situation in quantum theory, because only what we observe should be taken to be specified, it is not appropriate to assume the existence of a fixed, definite, unknown prior state, beyond the set B about which we have information. The theory was developed for the purposes of a fairly radical attack on the interpretation of quantum theory, involving many-worlds ideas and the abstract characterization of observers as finite information-processing structures, but deals with quantum inference problems of broad generality. (shrink)

Assertion is a speech act that stands at the intersection of the philosophy of language and social epistemology. It is a phenomenon that bears on such wide-ranging topics as testimony, truth, meaning, knowledge and trust. It is thus no surprise that analytic philosophers have devoted innumerable pages to assertion, trying to give the norms that govern it, its role in the transmission of knowledge, and most importantly, what assertion is, or how assertion is to be defined. -/- In this thesis (...) I attempt to show that all previous answers to the question “What is assertion?” are flawed. There are four major traditions in the literature: constitutive norm theories of assertion, accounts that treat assertion as the expression of speaker attitudes, accounts that treat assertion as a proposal to add some proposition to the common ground, and accounts that treat assertion as the taking of responsibility for some claim. Each tradition is explored here, the leading theories within the tradition developed, and then placed under scrutiny to demonstrate flaws within the positions surveyed. -/- I follow the work of G.E. Moore and William P. Alston, whilst drawing on the work of Robert Brandom in order to give a new bipartite theory of assertion. I argue that assertion consists in the explicit presentation of a proposition, along with a taking of responsibility for that proposition. Taking Alston’s explicit presentation condition and repairing it in order to deal with problems it faces, whilst combining it with Brandom’s responsibility condition, provides, I believe, the best account of assertion. (shrink)

A recovery of Georg Lukács's later thought on aesthetics, politics, and ontology and the first articulation of its unity, through the lens of the philosopher's writing on totality and reification.

Based on the French notion of terroir or ‘the taste of place,’ a certified geographical indication (GI) identifies an agro-food product as originating in a particular territory and suggests that its quality, reputation, or other characteristics are essentially or exclusively attributable to its geographical origin. Previous scholarship exploring the social construction of terroir has focused on how disparities in political, economic, and cultural power shape GI regulations, certification procedures, and territorial boundaries. While these works have considered knowledge as a resource (...) deployed through relations of authority, studies of GI implementation have not adequately considered an important aspect of power in contemporary politics: the epistemic authority to assert the legitimacy of knowledge and its relevance to policymaking. In contrast, in this article, I take the accomplishment of epistemic authority – to determine the ‘essential’ and ‘exclusive’ physical and/or cultural attributes of place that shape product character – as key to the social construction of terroir and the institutionalization of GI regulations. This process is explored through a case study of Ecuador’s 2013-2019 implementation of a GI for Galápagos Islands coffee. I draw on analysis of relevant policy and regulatory documents and semi-structured interviews with 21 key stakeholders to argue that analytical attention to the legitimacy and relevance of terroir knowledge explains how coffee producers were able to deploy authoritative knowledge to disrupt and reinforce relations of authority and challenge the terms and mechanisms of GI qualification. (shrink)

Temporary labor migration programs have been among the most controversial topics in discussions of immigration reform. They have been opposed by many, perhaps most, academics writing on immigration, by immigration reform activists, and by organized labor. This opposition has not been without some good reasons, as many historical temporary labor migration programs have led to significant injustice and abuse. However, in this paper I argue that a well-crafted temporary labor migration program is both compatible with liberal principles of justice and (...) likely to be an important part of a sensible immigration policy for the near future, at least. I show how the many injustices and high potential for abuse of earlier programs may be avoided. I also show good reason to favor a well-crafted temporary labor migration program over either the more likely alternative outcome of officially tight borders (which would almost certainly maintain our current dependence on large-scale unauthorized immigration) and the much less likely option of nearly open borders. As increased labor migration of all sorts is an intrinsic part of increased economic globalization, it is especially important to craft guidelines for just temporary labor migration programs if we are to both gain the advantages of globalization and protect the rights of workers. (shrink)

Virtue ethical interpretations of Nietzsche are increasingly viewed as a promising way to explain his moral philosophy, although current interpretations disagree on which character traits he regards as virtues. Of the first-, second-, and third-wave attempts addressing this question, only the latter can explain why Nietzsche denies that the same character traits are virtues for all individuals. Instead of positing the same set of character traits as Nietzschean virtues, third-wave theorists propose that Nietzsche only endorses criteria determining whether a specific (...) character trait is a virtue or vice for a specific individual. The article examines the criteria-based approaches of third-wave theorists Lester Hunt and Christine Swanton, showing how they urgently need revising to explain Nietzsche’s endorsement of non-acquisitive character traits. To do this I explore Nietzsche’s unpublished remarks on Spinoza, which I contend better explains why he understands non-acquisitive character traits as virtues. (shrink)

Proponents of the value ladenness of science rely primarily on arguments from underdetermination or inductive risk, which share the premise that we should only consider values where the evidence runs out or leaves uncertainty; they adopt a criterion of lexical priority of evidence over values. The motivation behind lexical priority is to avoid reaching conclusions on the basis of wishful thinking rather than good evidence. This is a real concern, however, that giving lexical priority to evidential considerations over values is (...) a mistake and unnecessary for avoiding the wishful thinking. Values have a deeper role to play in science. (shrink)

Spinoza’s ethical claims rest on a basic set of concepts that he regards as kinds of activity: striving, power, virtue, freedom, perfection, among others. Steven Nadler articulates a standard way of thinking about the relationship between these activity concepts: “a number of terms in Spinoza are co-extensive and refer to the same ideal human condition. We can set up the following equation for Spinoza: virtue = knowledge = activity = freedom = power = perfection. Necessarily, the more virtuous a person (...) is, the more knowledge he has, the more free, active and powerful he is, and the more he has achieved of human perfection.” This paper counters that Spinoza’s various notions of activity are not coextensive and do not refer to the same thing. In particular, Spinoza employs two basic notions of activity: striving and being an adequate cause. While these notions of activity are closely connected, they are not coextensive because a thing can strive without being an adequate cause of an effect. I defend that Spinoza’s various other activity concepts—virtue, perfection, reason and so forth—are pegged to one of these two basic notions of activity, so that Spinoza’s activity concepts are bifurcated into two categories, which are not coextensive with one another. Indeed, the members of each category may not be coextensive with one another. -/- Because these basic activity concepts play a fundamental role in Spinoza’s philosophical claims, this thesis has far-reaching implications. Most notably, the standard way of thinking mentioned above indicates that Spinoza’s basic ethical concepts, such as freedom and virtue, are coextensive with being an adequate cause. Since an adequate cause is the sole cause of some effect, this reading implies that freedom and virtue amount to being a sole cause and, thus, to being causally independent and self-sufficient. I argue, in contrast, that human freedom and virtue are coextensive with striving, which does not require causal independence. On this reading, human freedom and virtue can include instances of causal dependence, which implies that Spinoza’s ethics takes a more favorable view of human dependence, passivity and cooperation. (shrink)

While Spinoza’s political philosophy is often described as liberal, it is not always clear what this label means or whether it is warranted. Calling Spinoza ‘liberal’ implies that he belongs to a historical tradition of political philosophers, who formulated and defended claims, which later became identified as central to political liberalism. Consequently, clarifying how Spinoza is a liberal requires specifying precisely which liberal views he articulated and defended. This paper, first, examines the various ways that commentators have interpreted Spinoza as (...) defending liberal commitments. This examination shows that most commentators describe Spinoza as liberal on the grounds that his politics defends the value of individual political freedom, specifically of speech and thought. The paper, second, considers whether he upholds a claim that is important to contemporary liberalism, what is sometimes called the fundamental liberal principle. The paper concludes that Spinoza does not, which suggests that he does not sit as easily in the liberal tradition as some scholars have suggested. (shrink)

"What is gender? More importantly, what should gender look like in the 21st century? This book brings together philosophy with insights from feminist and transgender theory to argue for a position called 'ameliorative pluralism' about gender: that there should be more than two genders, and that each gender term should have multiple meanings. Matthew Cull argues that we should be pluralists about gender, developing and arguing for a position that more apt for contemporary transgender and feminist activism. The 21st (...) century requires a new way of thinking about gender. What Gender Should Be sets out to provide it"--. (shrink)

Asylum has become a highly charged political issue across developed countries, raising a host of difficult ethical and political questions. What responsibilities do the world's richest countries have to refugees arriving at their borders? Are states justified in implementing measures to prevent the arrival of economic migrants if they also block entry for refugees? Is it legitimate to curtail the rights of asylum seekers to maximize the number of refugees receiving protection overall? This book draws upon political and ethical theory (...) and an examination of the experiences of the United States, Germany, the United Kingdom and Australia to consider how to respond to the challenges of asylum. In addition to explaining why asylum has emerged as such a key political issue in recent years, it provides a compelling account of how states could move towards implementing morally defensible responses to refugees. (shrink)

The Impact of 9-11 on Religion and Philosophy is the sixth volume of the six-volume series The Day that Changed Everything? edited by Matthew J. Morgan. This volume features a foreword by John Esposito and contributors include Jean Bethke Elshtain, Philip Yancey, John Milbank, Ada Maria Isasi-Diaz, John Cobb and Martin Cook.

RAS GTPases play essential roles in normal development and are direct drivers of human cancers. Three decades of study have failed to wholly characterize pathways stimulated by activated RAS, driven by engagement with ‘effector’ proteins that have RAS binding domains (RBDs). Bone fide effectors must bind directly to RAS GTPases in a nucleotide‐dependent manner, and this interaction must impart a clear change in effector activity. Despite this, for most proteins currently deemed effectors there is little mechanistic understanding of how binding (...) to the GTPase alters protein function. There has also been limited effort to comprehensively resolve the specificity of effector binding to the full array of RAS superfamily GTPase proteins. This review will summarize what is known about RAS‐driven activation for an array of potential effector proteins, focusing on structural and mechanistic effects and highlighting how little is still known regarding this key paradigm of cellular signal transduction. (shrink)

The witch-hunt of the Burgundian town of Arras in 1459-1460 was the first large- scale, state-sponsored witch-hunt of Western Europe. However, immediately following this witch-hunt we still find evidence of a reluctance to accept the realities of witchcraft among the populace, made plain in the official appeal record of the accused Seigneur Colard de Beaufort at the parlement de Paris. Scepticism of this kind stirred the Dominican cleric Johannes Tinctor out of retirement to write a vicious demonological treatise to convince (...) the courts of Burgundy and France of the existence and dangers of a sect called vaudois, a term that had come to refer to witches. This essay closely examines Tinctor's heavy use of crusading imagery in his Invectives contre la secte de vauderie to justify and rationalize his arguments for duke Philip the Good of Burgundy and his court, a court renowned for consistent but empty promises of crusade and an elaborate culture bloated with an idealized infatuation with chivalric virtue and romance. In the autumn of the middle ages, when the traditional eastern crusade against "Saracens" had become frustratingly difficult to organize, what could be more appealing to a court so starved for crusade than a cry for war against an even greater enemy hiding amongst the populace, threatening Christendom from within? (shrink)

This article sketches the main features of traditional philosophical models of evidence, indicating idealizations in such models that it regards as doing more harm than good. It then proceeds to elaborate on an alternative model of evidence that is functionalist, complex, dynamic, and contextual, a view the author calls dynamic evidential functionalism (DEF). This alternative builds on insights from philosophy of scientific practice, Kuhnian philosophy of science, pragmatist epistemology, philosophy of experimentation, and functionalist philosophy of mind. Along the way, the (...) article raises concerns about the total evidence condition, requirements of certainty or incorrigibility on evidence, and accounts that restrict the type of things that can serve as evidence (to, for example, sense data, facts about particulars). DEF can also help us see the special value of novel predictions and experiments as evidence, as well as help us think about how to critically evaluate the putative evidence to determine whether it is evidence. (shrink)

During his more than fifty-year writing and teaching career, Horace M. Kallen (1882-1974), the American Jewish philosopher who coined the term "cultural pluralism," incorporated into his pragmatism-infused philosophy of life a number of different sciences, from racial science to psychology and physics. Part biography, part cultural history, "Horace Kallen Confronts America" offers fresh insight into the larger question of how social discourses shape modern American Jewish identity.

This book argues that the criterion of rationality Hegel employs in his argument that the modern state as he conceptualizes it is rational is the holistic inferential system of concepts he refers to as the Concept and depicts in the Science of Logic. The book then attempts to explain Hegel’s political philosophy as it is articulated in the Philosophy of Right in terms of the logical and metaphysical requirements of the Science of Logic.

In his long 1957 paper, “The Theory of the Universal Wave Function”, Hugh Everett III made some significant preliminary steps towards the application and generalization of Shannon’s information theory to quantum mechanics. In the course of doing so, he conjectured that, for a given wavefunction on a compound space, the Schmidt decomposition maximises the correlation between subsystem bases. This is proved here.

Fezf1 and Fezf2 are highly conserved transcription factors that were first identified by their specific expression in the anterior neuroepithelium of Xenopus and zebrafish embryos. These proteins share an N‐terminal domain with homology to the canonical engrailed repressor motif and a C‐terminal DNA binding domain containing six C2H2 zinc‐finger repeats. Over a decade of study indicates that the Fez proteins play critical roles during nervous system development in species as diverse as fruit flies and mice. Herein we discuss recent progress (...) in understanding the functions of Fezf1 and Fezf2 in neurogenesis and cell fate specification during mammalian nervous system development. Going forward we believe that efforts should focus on understanding how expression of these factors is precisely regulated, and on identifying target DNA sequences and interacting partners. Such knowledge may reveal the mechanisms by which Fezf1 and Fezf2 accomplish both independent and redundant functions across diverse tissue and cell types. (shrink)

How are we to understand Descartes' view on the power and scope of reason? According to a common view, Descartes traffics in what I call 'theocentric rationalism.' Theocentric rationalism holds that human reason resembles divine reason, according to which God created the world. A hallmark of this view is the notion that knowledge should be analyzed and evaluated according to the standards of cognition achievable by God. ;My dissertation argues that Descartes resisted treating human reason as resembling divine reason. This (...) is supported by Descartes' theological voluntarism which denies that God is bound by the standards of human reason. Rather, Descartes conceived of reason as a natural power. He argued that reason is a power of mental substances, as much a part of the natural world as powers belonging to their counterpart, bodily substances. This conception of reason led Descartes to a view which I call "naturalistic rationalism." It holds that human knowledge is subject to the constraints and limitations imposed by our natural faculties human knowledge should be analyzed and evaluated according to the standards of cognition achievable by humans, given these limitations. According to my interpretation, Descartes did not seek to justify human reason by recourse to independent standards, such as divine reason. ;My case for this interpretation takes the form of a narrative tracing the development of Descartes' views on reason. Descartes' theory of reason emerged from his first systematic project, the method. Because Descartes held that method must employ the cognitive faculties properly, this early work, particularly the unpublished Regulae ad Directionem Ingenii , provides extensive discussions of reason, its proper function and its limits. I argue that Descartes' mature metaphysical work continued to uphold the central claims of his early theory of reason, in particular, the view that reason is a natural power, subject to natural constraints. ;This reading draws attention to the often neglected philosophical influence of Descartes' close friend, Marin Mersenne. Furthermore, my reading demonstrates the continuity of Descartes' early and later work. Most importantly, my reading allows us to better appreciate the significant differences between Descartes' rationalism and other rationalists. (shrink)

This chapter contains sections titled: The Philosophical Background to Method Descartes' Method Descartes' Successors: Malebranche and Spinoza on Method.

A far-reaching and influential view in evolutionary biology claims that species are cohesive units held together by gene flow. Biologists have recognized empirical problems facing this view; after sharpening the expression of the view, we present novel conceptual problems for it. At the heart of these problems is a distinction between two importantly different concepts of cohesion, what we call integrative and response cohesion. Acknowledging the distinction problematizes both the explanandum of species cohesion and the explanans of gene flow that (...) are central to the view we discuss. We conclude by tracing four broader implications for the study and conceptualization of species. (shrink)